Multi-Round compared to Real-Time Delphi for consensus in core outcome set (COS) development: a randomised trial;Fiona A. Quirke, Patricia Healy, Elaine Ní Bhraonáin, Mandy Daly, Linda Biesty, Tim Hurley, Karen Walker, Shireen Meher, David M. Haas, Frank H. Bloomfield, Jamie J. Kirkham, Eleanor J. Molloy & Declan Devane
NEPTuNE scholar, Fiona Quirke, has had her second paper published in the Trials Journal. The paper refers to a protocol for a randomised trial comparing multi-round and real-time Delphi survey methods to achieve consensus in Core Outcome Set Development.
COHESION: core outcomes in neonatal encephalopathy (protocol); Fiona A. Quirke, Patricia Healy, Elaine Ní Bhraonáin, Mandy Daly, Linda Biesty, Tim Hurley, Karen Walker, Shireen Meher, David M. Haas, Frank H. Bloomfield, Jamie J. Kirkham, Eleanor J. Molloy & Declan Devane
This paper presents the protocol for the COHESION project, outlining how the COHESION team will develop a core outcome set (COS) for neonatal encephalopathy.
The COS will define the most important outcomes that should be measured and recorded in trials to determine the effect of treatments for neonatal encephalopathy. These important outcomes will be contributed by parents, healthcare providers and researchers with experience/expertise of neonatal encephalopathy.
The Bayley Scales of Infant and Toddler Development is a gold standard series of behavioural assessments used by clinicians and researchers to assess the developmental functioning of young children. This paper aims to discuss how to pick an appropriate developmental assessment and outlines indications for the use of the Bayley-III in comparison with other commonly used tools for the assessment of development in children. It discusses the value of the Bayley-III and some of its limitations.
A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial, Andreea M Pavel, Janet M Rennie, Linda S de Vries, Mats Blennow, Adrienne Foran, Divyen K Shah, Ronit M Pressler, Olga Kapellou, Eugene M Dempsey, Sean R Mathieson, Elena Pavlidis, Alexander C van Huffelen, Vicki Livingstone, Mona C Toet, Lauren C Weeke, Mikael Finder, Subhabrata Mitra, Deirdre M Murray, William P Marnane, Geraldine B Boylan
Despite the availability of continuous conventional electroencephalography (cEEG), accurate diagnosis of neonatal seizures is challenging in clinical practice. Algorithms for decision support in the recognition of neonatal seizures could improve detection. We aimed to assess the diagnostic accuracy of an automated seizure detection algorithm called Algorithm for Neonatal Seizure Recognition (ANSeR).
Diffusion tensor imaging (DTI) during the first few days of life can be used to assess brain injury in neonates with neonatal encephalopathy for outcome prediction. The goal of this review was to identify specific white matter tracts of interest that can be quantified by DTI as being altered in neonates with this condition, and to investigate its potential prognostic ability.
SNI (Severe Neurological Impairment) is a term used widely in medical literature and this review demonstrates that there is wide variation in how it is applied. With the introduction of Core Outcome Sets and Reporting Guidelines, there is an emphasis on having a uniform definition of a patient cohort. An improved definition will provide better accuracy in assessing prevalence, conducting research, planning medical resources and evaluating outcomes.
Click here to read more about the SERENITY programme.
- Coagulation Profiles Are Associated with Early Clinical Outcomes in Neonatal Encephalopathy. Sweetman D, Kelly LA, Zareen Z, Nolan B, Murphy J, Boylan G, Donoghue V, Molloy EJ.
- Management of Multi Organ Dysfunction in Neonatal Encephalopathy. O’Dea M, Sweetman D, Bonifacio SL, El-Dib M, Austin T, Molloy EJ. Front Pediatr. 2020 May 15;8:239
- Troponin T correlates with MRI results in neonatal encephalopathy. Sweetman DU, Kelly L, Hurley T, Onwuneme C, Watson RWG, Murphy JFA, Slevin M, Donoghue V, Molloy EJ.Acta Paediatr. 2020 Nov;109(11):2266-2270.
- Biomarkers of multiorgan injury in neonatal encephalopathy. Aslam S, Molloy EJ.Biomark Med. 2015;9(3):267-75.
- Neonatal Encephalopathy: Need for Recognition of Multiple Etiologies for Optimal Management. Aslam S, Strickland T, Molloy EJ.
- Upregulation of Immune Inflammatory gene expression in Neonatal Encephalopathy. M O’Dea, L Kelly, O’Leary JJ, Sweetman D, EJ Molloy. Pediatric Research published abstract 2017.
- Multi-Organ Dysfunction Scoring In Neonatal Encephalopathy: MODE score. Sweetman D, Donoghue V, Boylan GB, Segurado R, Murphy JF, Molloy EJ. Pediatric Research published abstract 2017.
- Serial cytokine alterations and abnormal neuroimaging in newborn infants with encephalopathy. O’Hare FM, Watson RW, O’Neill A, Segurado R, Sweetman D, Downey P, Mooney E, Murphy J, Donoghue V, Molloy EJ. Acta Paediatr. 2017 Apr;106(4):561-567.
- Perinatal Asphyxia and Erythropoietin and VEGF: Serial Serum and Cerebrospinal Fluid Responses. Sweetman DU, Onwuneme C, Watson WR, Murphy JF, Molloy EJ. Neonatology. 2017;111(3):253-259.
- Renal function and novel urinary biomarkers in infants with neonatal encephalopathy. Sweetman DU, Onwuneme C, Watson WR, O’Neill A, Murphy JF, Molloy EJ. Acta Paediatr. 2016 Nov;105(11):e513-e519.
Click here to read more about the NIMBUS project.
Parental involvement in a multidisciplinary PhD programme in neonatal brain injury: Eleanor J. Molloy, Mandy Daly, Paul Ryan, Sabina BrennanElaine Ni Bhraonain, Geraldine Boylan,
Parental and patient and public involvement (PPI) involvement is a core element of the Neonatal Brain Consortium Ireland Ireland (NBCI) since its inception. PPI representatives were critical to the development of the Consortium and the animations for parent information as well as the NEPTUNE Neonatal Encephalopathy PhD programme in which they are core members involved in PhD supervision, publications, study days and educational outreach. Key outputs have also included national clinical guidelines and parent information.
Click here to read more about the NEPTuNE programme.